Creative Biogene's CRISPR Library Screening Service aims to utilize the CRISPR/Cas9 system to disrupt gene function at the genome level, assisting scientists in rapidly identifying target genes, understanding their functions, and discovering new drug targets.

In recent years, CRISPR technology has emerged as a transformative tool in the field of biology. CRISPR library screening is a high-throughput screening method based on the CRISPR/Cas9 gene editing system, designed to interfere with the genome using a large-scale sgRNA library to discover new drug targets associated with specific phenotypes or biological processes. This technology employs precisely designed sgRNA sequences introduced into target cells or organisms, facilitating screening under drug pressure or cell sorting conditions to identify genes closely associated with the target phenotype. It provides critical molecular targets and mechanistic insights for drug development and accelerates the refinement of gene function studies and disease models. At the same time, the application of CRISPR library screening technology faces challenges such as off-target effects, complex sgRNA design, standardization of screening conditions, limitations in library coverage, and complexity in data analysis.

Creative Biogene's CRISPR Library Screening Service effectively addresses these challenges by integrating advanced bioinformatics analysis techniques and precise experimental design. Our platform enables precise design and validation of sgRNA libraries optimizes screening conditions and analyzes data comprehensively to ensure high reliability and repeatability of screening results, providing efficient and accurate target discovery and gene function research services for our customers.